Cereb Cortex 6:354–361Īine CJ, Stephen JM, Christner R, Hudson D, Best E (2003) Task relevance enhances early transient and late slow-wave activity of distributed cortical sources. Int J Neurosci 80:79–104Īine CJ, Supek S, George JS, Ranken D, Lewine J, Sanders J, Best E, Tiee W, Flynn ER, Wood CC (1996) Retinotopic organization of human visual cortex: departures from the classical model. Academic Press, Amsterdam, pp 93–142Īine CJ, Supek S, George JS (1995) Temporal dynamics of visual-evoked neuromagnetic sources: effects of stimulus parameters and selective attention. In: Zanni A, Proverbio AM (eds) The cognitive electrophysiology of mind and brain. Electroencephalogr Clin Neurophysiol 82:225–236Īine CJ, Stephen JM (2002) MEG studies of visual processing.
J Neurophysiol 61:900–917Īhlfors SP, Ilmoniemi RJ, Hamalainen MS (1992) Estimates of visually evoked cortical currents. KeywordsĪertsen AM, Gerstein GL, Habib MK, Palm G (1989) Dynamics of neuronal firing correlation: modulation of “effective connectivity”. We will also briefly review the organization of the visual system to provide an overall appreciation for the intricacies of the visual system as well as providing some historical context for the manner in which certain studies have been designed. In this chapter we will discuss some of the technical issues we encountered while developing and testing paradigms for basic vision, attention, and working memory and will highlight ways to avoid some of these potential confounds. However, characterization of neural circuits involved in disorders of the nervous system (i.e., neuromagnetic mapping of networks of regions and their temporal dynamics) presents a tremendous technical challenge. We focused on the former with the ultimate goal of developing/testing new stimulus paradigms and clinical applications for assessing cognitive functions such as working memory since several neuropsychiatric and neurological disorders such as schizophrenia and dementia reveal deficits in working memory circuits.
Historically, MEG investigations of the visual system either attempted to (1) corroborate findings from invasive monkey or basic psychophysical studies as an indirect way to validate MEG results or (2) enhance previously demonstrated clinical event-related potential findings (ERPs) (e.g., multiple sclerosis patients reveal longer ERP peak latencies).
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